Polymorphic acetylation of nitrazepam.

نویسندگان

  • A K Karim
  • D A Evans
چکیده

Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Impaired nitrazepam metabolism in hypothyroidism ROSE

Nitrazepam is frequently used for sedation in elderly patients, some of whom may be particularly sensitive to its central effects. There have been no previous reports of delayed metabolism of nitrazepam in association with hypothyroidism. The following case report illustrates such a delay and also demonstrates some of the atypical features of hypothyroidism at presentation in elderly subjects.

متن کامل

Prolonged use of nitrazepam for epilepsy in children with tuberous sclerosis.

A case note study of 90 children with tuberous sclerosis showed that 56 had taken nitrazepam for seizures for from one month to 13 years. In 38 children nitrazepam was withdrawn but only two had immediate major seizures. Given that sleepiness, deterioration in motor skills, or ataxia seems to be associated in some children with treatment with nitrazepam, doctors may wish to review their long te...

متن کامل

Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative.

The behavioral effect of brotizolam was investigated in mice and rats, in comparison with those of diazepam, nitrazepam and estazolam. Locomotor activity of rats in an open field situation was slightly increased with smaller doses of brotizolam and estazolam and with larger doses of nitrazepam, while it was decreased with large doses of brotizolam and estazolam. The anticonflict effect of broti...

متن کامل

Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.

The polymorphic acetyltransferase isozyme expressed in homozygous rapid acetylator inbred hamster liver cytosol was purified over 2000-fold by sequential Q-Sepharose fast-flow anion-exchange chromatography, Sephacryl S-200 high-resolution size-exclusion chromatography, Mono Q anion-exchange fast-protein liquid chromatography, and preparative polyacrylamide gel electrophoresis. The isozyme migra...

متن کامل

Quantitative determination of medazepam, diazepam, and nitrazepam in whole blood by flame-ionization gas-liquid chromatography.

Accurate methods are described for the qualitative and quantitative determination of medazepam, diazepam, and nitrazepam in 5 ml of whole blood. Medazepam and diazepam are analyzed intact and nitrazepam is chromatographed as its trimethylsilyl derivative by flame-ionization gas-chromatography on “1% OV-17.” A supplementary column of “2% OV-1” is used to separate nitrazepam TMS from diazepam whe...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Journal of medical genetics

دوره 13 1  شماره 

صفحات  -

تاریخ انتشار 1976